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Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 76-84 doi: 10.1007/s11684-015-0426-7

Abstract:

Anti-β2 glycoprotein I (anti-β2GP I ) antibodies are important>GP I complex.The interaction between the anti-β2GP I /β2GP I complex and plateletsOur results revealed that the anti-β2GP I /β2GP I complex was able toResults showed that the anti-β2GP I /β2GP I complex induced platelet

Keywords： anti-β2GP I /β2GP I complex     platelet     GP I bα     apoER2'     thrombosis    

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Association of gene variants with juvenile amyotrophic lateral sclerosis

Frontiers of Medicine doi: 10.1007/s11684-023-1005-y

Abstract: characterized by progressive degeneration of motor neurons, and it demonstrates high clinical heterogeneity and complexA variation within <i>TRMT2Bi> (c.1356G>T; p.K452N) was identified to be associated with ALS in a familyin patient-originated lymphoblastoid cell lines and <i>TRMT2Bi> interfering HEK293 cells.Further, <i>TRMT2Bi> variations overexpression cells also displayed decreased ND1.In conclusion, a novel JALS-associated gene called <i>TRMT2Bi> was identified, thus broadening the

Keywords： <i>TRMT2Bi>     amyotrophic lateral sclerosis     mitochondrial complex I     tRNA methylation     reactive oxygen    

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Presentation of regression analysis, GP and GMDH models to predict the pedestrian density in various

Iraj BARGEGOL; Seyed Mohsen HOSSEINIAN; Vahid NAJAFI MOGHADDAM GILANI; Mohammad NIKOOKAR; Alireza OROUEI

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 2,   Pages 250-265 doi: 10.1007/s11709-021-0785-x

Abstract: was investigated in different pedestrian facilities, including 1 walkway, 2 sidewalks, 2 signalizedcrosswalks and 2 mid-block crosswalks.Finally, two prediction models of density were obtained using genetic programming (GP) and group methodResults also indicated that GP had a higher <i>Ri>2 than GMDH in the prediction of pedestriandensity in terms of flow rate and <i>SMSi>, suggesting that GP was better able to model <i>SMSi>

Keywords： pedestrian density     regression analysis     GP model     GMDH model    

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SARS-CoV-2 Entry Factors: <i>ACE2i> and <i>TMPRSS2i> Are Expressed in Peri-Implantation Embryos and Article

Wei Chen, Peng Yuan, Ming Yang, Zhiqiang Yan, Siming Kong, Jie Yan, Xixi Liu, Yidong Chen, Jie Qiao, Liying Yan

Engineering 2020, Volume 6, Issue 10,   Pages 1162-1169 doi: 10.1016/j.eng.2020.07.013

Abstract:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world, leadingAngiotensin-converting enzyme 2 (ACE2) is the receptor of both severe acute respiratory syndrome coronavirus(SARS-CoV) and SARS-CoV-2.In order to investigate the potential risk of SARS-CoV-2 vertical transmission, we explored ACE2/em> and TMPRSS2, indicating SARS-CoV-2 infection susceptibility.

Keywords： SARS-CoV-2     ACE2     Vertical transmission     Placenta     Peri-implantation    

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Evaluation of H2 on the Evolution Mechanism of NO<i>xi> Storage and Reductionover Pt–Ba–Ce/γ-Al2O3 Catalysts Article

Pan Wang, Jing Yi, Chuan Sun, Peng Luo, Lili Lei

Engineering 2019, Volume 5, Issue 3,   Pages 568-575 doi: 10.1016/j.eng.2019.02.005

Abstract:

In this investigation, Pt–Ba–Ce/γ-Al2O3 catalysts were preparedby incipient wetness impregnation and experiments were performed to evaluate the influence of H2 onThe physical and chemical properties of the Pt–Ba–Ce/γ-Al2O3sub>, whose peaks were observed in X-ray diffraction (XRD) spectra, dispersed well on the γ-Al2O3/sub> exposure (i.e., 30 s, 45 s, and 60 s) was extended.

Keywords： Pt–Ba–Ce/γ-Al2O3 catalysts     Physicochemical properties     NO<i>xi> storageand reduction     NO<i>xi> emission     H2 reductant    

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Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 680-689 doi: 10.1007/s11684-018-0673-5

Abstract: Anti- glycoprotein I (anti- GPI) antibodies are important contributors to the development of thrombosisAnti- GPI antibody complexes with GPI are well known to activate monocytes and endothelial cells viaBy contrast, the interaction of anti- GPI/ GPI complexes with platelets has not been extensively studiedFurthermore, SB203580 inhibits anti- GPI/ GPI complex-induced platelet activation.Thrombus formation decreased in mice after treatment with anti- GPI/ GPI complexes.

Keywords： anti-   

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Expression of heat shock protein gp96 in osteosarcoma and its clinical significance

GUO Weichun, CHEN Anmin

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 200-203 doi: 10.1007/s11684-008-0038-6

Abstract: This study aims to detect the expression of heat shock protein gp96 (HSPgp96) in osteosarcoma and exploreits role in anti-tumor immunity.and it may be a significant index for judgment of malignancy degree and an important target site of anti-tumor
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<i>RR1i> and <i>RR2i> gene deletion affects the immunogenicity of a live attenuated pseudorabies

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 81-86 doi: 10.15302/J-FASE-2016088

Abstract: As virulence-determining genes, and encode the small subunit and large subunit of viral ribonucleotide reductase (RR) in pseudorabies virus which have been extensively studied in mice. However, their role in pigs has not been adequately investigated. In this study, we deleted and genes based on a / / triple gene-deleted pseudorabies virus and tested its efficacy in pigs as a vaccine candidate. The rescued virus showed similar growth properties and plaque size as its parent strain. In an animal study, the virus could elicit humoral immune responses shown by generation of gB-specific antibodies and virus neutralizing antibodies. However, vaccination could not provide protection against virulent pseudorabies virus challenge since vaccinated pigs showed clinical pseudorabies-specific syndromes. The deficiency in protection may due to the generation of late and low levels of gB antibodies and virus neutralizing antibodies.

Keywords： pseudorabies virus     <i>RR1i> and <i>RR2i>     ribonucleotide reductase     vaccine candidate    

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NO<i>xi> and H2S formation in the reductive zone of air-staged combustion of

Jinzhi CAI, Dan LI, Denggao CHEN, Zhenshan LI

Frontiers in Energy 2021, Volume 15, Issue 1,   Pages 4-13 doi: 10.1007/s11708-020-0804-y

Abstract: Low NO combustion of blended coals is widely used in coal-fired boilers in China to control NO emission; thus, it is necessary to understand the formation mechanism of NO and H S during the combustion of blended coals. This paper focused on the investigation of reductive gases in the formation of NO and H S in the reductive zone of blended coals during combustion. Experiments with Zhundong (ZD) and Commercial (GE) coal and their blends with different mixing ratios were conducted in a drop tube furnace at 1200°C–1400°C with an excessive air ratio of 0.6–1.2. The coal conversion and formation characteristics of CO, H S, and NO in the fuel-rich zone were carefully studied under different experimental conditions for different blend ratios. Blending ZD into GE was found to increase not only the coal conversion but also the concentrations of CO and H S as NO reduction accelerated. Both the CO and H S concentrations inblended coal combustion increase with an increase in the combustion temperature and a decrease in the excessive air ratio. Based on accumulated experimental data, one interesting finding was that NO and H S from blended coal combustion were almost directly dependent on the CO concentration, and the CO concentration of the blended coal combustion depended on the single char gasification conversion.Thus, CO, NO , and H S formation characteristics from blended coal combustion can be well predicted by single char gasification kinetics.

Keywords： blended coal combustion     NO<i>x i>formation     H2S formation     air staged combustion    

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<i>Ni>-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probesfor <i>in vivoi> cell H2S imaging

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 64-71 doi: 10.1007/s11705-021-2048-8

Abstract: Heterocyclic compound quinoline and its derivatives exist in natural compounds and have a broad spectrum of biological activity. They play an important role in the design of new structural entities for medical applications. Similarly, indoles and their derivatives are found widely in nature. Amino acids, alkaloids and auxin are all derivatives of indoles, as are dyes, and their condensation with aldehydes makes it easy to construct reaction sites for nucleophilic addition agents. In this work, we combine these two groups organically to construct a rapid response site (within 30 s) for H S, and at the same time, a ratiometric fluorescence response is presented throughout the process of H S detection. As such, the lower detection limit can reach 55.7 nmol/L for H S. In addition, cell imaging shows that this probe can be used for the mitochondrial targeted detection of endogenous and exogenous H S. Finally, this probe application was verified by imaging H S in nude mice.

Keywords： heterocyclic compound     hydrogen sulfide     ratiometric     mitochondrial targeted    

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><i>In situi> growth of phosphorized ZIF-67-derived amorphous CoP/Cu2O@CF electrocatalyst

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1430-1439 doi: 10.1007/s11705-023-2320-1

Abstract: Herein, we report an <i>in situi> phosphorization of zeolitic imidazole frameworks (ZIF-67) to generateThe intermediate product was phosphorized to obtain final electrocatalyst (CoP/Cu2O@CF) withwas only 62 mV with the Tafel slope of 83 mV·dec–1 at a current density of 10 mA·cm–2i>-band center of CoP downshifted after bonding with ZIF-67 and the Gibbs free energy (Δ<i>Gi>2O@CF catalyst, which will act as

Keywords： CoP/Cu2O@CF     electrocatalyst     phosphorization     HER     DFT    

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High <i>Sni>-2 Docosahexaenoic Acid Lipids for Brain Benefits, and Their Enzymatic Syntheses: A Review Review

Jun Jin, Qingzhe Jin, Xingguo Wang, Casimir C. Akoh

Engineering 2020, Volume 6, Issue 4,   Pages 424-431 doi: 10.1016/j.eng.2020.02.009

Abstract: DHA incorporated at the sn-2 position of lipids is well absorbed by intestinal mucosa and utilizedbeneficial effects of DHA on the human brain, this review introduces the positional difference (sn-2To achieve high sn-2 DHA in diets, it is suggested that sn-2 DHA lipids be enzymaticallyThese types of diets will benefit individuals with strong needs for sn-2

Keywords： Docosahexaenoic acid， Sn-2 docosahexaenoic acid，Monoacylglycerol，Brain，Gut-brain axis，Structured lipid    

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Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 729-746 doi: 10.1007/s11684-022-0978-2

Abstract: The effect of anti-programmed cell death 1 (anti-PD-1) immunotherapy is limited in patients with hepatocellularThe response to anti-PD-1 treatment is associated with <i>A. muciniphilai> abundance in many tumorsHere, anti-PD-1 treatment decreased <i>A. muciniphilai> abundance in the colon, but increased YAP1<i>Yap1i> knockout enhanced anti-PD-1 efficacy.anti-PD-1 therapy.

Keywords： hepatocellular carcinoma     YAP1     <i>Akkermansia muciniphilai>     anti-PD-1     dihydroartemisinin     bile acid    

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photocatalytic performance through the evolution of the properties due to the phase transition from NaBiO·2HO

Frontiers in Energy 2022, Volume 16, Issue 3,   Pages 471-482 doi: 10.1007/s11708-021-0778-4

Abstract: The phase transition process of a photocatalytic system from NaBiO3·2H2O to BiO2–<i>xi> has been investigated to understand the important factors that affectIt is found that a proper amount of BiO2–<i>xi> on the surface of NaBiO3A fully covered BiO2–<i>xi> on NaBiO3·2H2O results in aAn over long hydrothermal process can result in BiO2–<i>xi> with reduced oxygen

Keywords： composite construction     distribution     BiO2–<i>xi>     evolution of defects    

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Photosynthesis and related metabolic mechanism of promoted rice (<i>Oryza sativai> L.) growth by TiO2 nanoparticles

Yingdan Zhang, Na Liu, Wei Wang, Jianteng Sun, Lizhong Zhu

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 6, doi: 10.1007/s11783-020-1282-5

Abstract: Abstract • The rice growth was promoted by nano-TiO2 of 0.1–100 mg/L. • Nano-TiO2 enhanced the energystorage in photosynthesis. • Nano-TiO2 reduced energy consumption in carbohydrate metabolism and TCATitanium dioxide nanoparticle (nano-TiO2), as an excellent UV absorbent and photo-catalyst, has beenWe proposed that nano-TiO2 in soil can promote crop yield through photosynthetic and metabolic disturbanceResults showed that rice biomass was increased >30% at every applied dosage (0.1–100 mg/L) of nano-TiO2.

Keywords： Nano-TiO2     Rice     Photosynthesis     Metabolomics     Energy storage    

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Title Author Date Type Operation

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Journal Article

Association of gene variants with juvenile amyotrophic lateral sclerosis

Journal Article

Presentation of regression analysis, GP and GMDH models to predict the pedestrian density in various

Iraj BARGEGOL; Seyed Mohsen HOSSEINIAN; Vahid NAJAFI MOGHADDAM GILANI; Mohammad NIKOOKAR; Alireza OROUEI

Journal Article

SARS-CoV-2 Entry Factors: <i>ACE2i> and <i>TMPRSS2i> Are Expressed in Peri-Implantation Embryos and

Wei Chen, Peng Yuan, Ming Yang, Zhiqiang Yan, Siming Kong, Jie Yan, Xixi Liu, Yidong Chen, Jie Qiao, Liying Yan

Journal Article

Evaluation of H2 on the Evolution Mechanism of NO<i>xi> Storage and Reductionover Pt–Ba–Ce/γ-Al2O3 Catalysts

Pan Wang, Jing Yi, Chuan Sun, Peng Luo, Lili Lei

Journal Article

Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

Journal Article

Expression of heat shock protein gp96 in osteosarcoma and its clinical significance

GUO Weichun, CHEN Anmin

Journal Article

<i>RR1i> and <i>RR2i> gene deletion affects the immunogenicity of a live attenuated pseudorabies

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Journal Article

NO<i>xi> and H2S formation in the reductive zone of air-staged combustion of

Jinzhi CAI, Dan LI, Denggao CHEN, Zhenshan LI

Journal Article

<i>Ni>-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probesfor <i>in vivoi> cell H2S imaging

Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin

Journal Article

><i>In situi> growth of phosphorized ZIF-67-derived amorphous CoP/Cu2O@CF electrocatalyst

Journal Article

High <i>Sni>-2 Docosahexaenoic Acid Lipids for Brain Benefits, and Their Enzymatic Syntheses: A Review

Jun Jin, Qingzhe Jin, Xingguo Wang, Casimir C. Akoh

Journal Article

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD

Journal Article

photocatalytic performance through the evolution of the properties due to the phase transition from NaBiO·2HO

Journal Article

Photosynthesis and related metabolic mechanism of promoted rice (<i>Oryza sativai> L.) growth by TiO2 nanoparticles

Yingdan Zhang, Na Liu, Wei Wang, Jianteng Sun, Lizhong Zhu

Journal Article